SPP1 is a plasma biomarker associated with the dia gnosis and prediction of prognosis in sepsis.

ABSTRACT: In this study, peripheral whole blood samples from 22 hospitalized patients and 10 healthy individuals were analyzed using a combination of Data Independent Acquisition (DIA) and Enzyme-Linked Immunosorbent Assay (ELISA) techniques to identify differentially expressed proteins (DEPs) in sepsis patients' plasma. The aim was to provide accurate and detailed biomarkers, such as SPP1, for determining the pathological stages of sepsis. SPP1, known as osteopontin1 is a pleiotropic protein with a wide distribution and multifunctional effects. Its protein expression is associated with inflammatory changes, including variations in expression levels in infectious diseases, allergic diseases, and situations involving tissue damage. The registration number was ChiCTR1900021261.The full date of first r

SUBMITTER: Shen YZ 

PROVIDER: S-EPMC11549466 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature