Arginine impacts aggregation, biofilm formation, and antibiotic susceptibility in Enterococcus faecalis.

ABSTRACT: Enterococcus faecalis is a commensal bacterium in the gastrointestinal (GI) tract of humans and other organisms. E. faecalis also causes infections in root canals, wounds, the urinary tract, and on heart valves. E. faecalis metabolizes arginine through the arginine deiminase pathway, which converts arginine to ornithine and releases ATP, ammonia, and CO₂. E. faecalis arginine metabolism also affects virulence of other pathogens during co-culture. E. faecalis may encounter elevated levels of arginine in the GI tract or the oral cavity, where arginine is used as a dental therapeutic. Little is known about how E. faecalis responds to growth in arginine in the absence of other bacteria. To address this, we used RNAseq and additional assays t

SUBMITTER: Snell AP 

PROVIDER: S-EPMC11549559 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature