Feasibility of Delivering 5-Day Normobaric Hypoxia Breathing in a Hospital Setting.

ABSTRACT:

Background

Beneficial effects of breathing at [Formula: see text] < 0.21 on disease outcomes have been reported in previous preclinical and clinical studies. However, the safety and intra-hospital feasibility of breathing hypoxic gas for 5 d have not been established. In this study, we examined the physiologic effects of breathing a gas mixture with [Formula: see text] as low as 0.11 in 5 healthy volunteers.

Methods

All 5 subjects completed the study, spending 5 consecutive days in a hypoxic tent, where the ambient oxygen level was lowered in a stepwise manner over 5 d, from [Formula: see text] of 0.16 on the first day to [Formula: see text] of 0.11 on the fifth day of the study. All the subjects returned to an environment at room air on the sixth day. The subjects' [Formula

SUBMITTER: Berra L 

PROVIDER: S-EPMC11549621 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature