The Impact of Increased PEEP on Hemodynamics, Respiratory Mechanics, and Oxygenation in Pediatric ARDS.

ABSTRACT:

Background

PEEP is a cornerstone treatment for children with pediatric ARDS. Unfortunately, its titration is often performed solely by evaluating oxygen saturation, which can lead to inadequate PEEP level settings and consequent adverse effects. This study aimed to assess the impact of increasing PEEP on hemodynamics, respiratory system mechanics, and oxygenation in children with ARDS.

Methods

Children receiving mechanical ventilation and on pressure-controlled volume-guaranteed mode were prospectively assessed for inclusion. PEEP was sequentially changed to 5, 12, 10, 8 cm H₂O, and again to 5 cm H₂O. After 10 min at each PEEP level, hemodynamic, ventilatory, and oxygenation variables were collected.

Results

A total of 31 subjects were included,

SUBMITTER: Junqueira FM 

PROVIDER: S-EPMC11549636 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature