Ceftazidime-avibactam treatment dilemma of bla_KPC-2-containing Klebsiella pneumoniae due to the development of co-existence of mixed strains carrying bla_KPC-2 or bla_KPC-33 in lung transplant recipients.

ABSTRACT:

Background

Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant threat to immunocompromised populations, including lung transplant recipients. This study investigates mixed CRKP strains carrying either bla_KPC-2 or bla_KPC-33 following ceftazidime-avibactam (CAZ/AVI) exposure, particularly in the context of lung transplantation. Mixed CRKP strains with shifting resistance phenotypes were frequently identified in patients exposed to CAZ/AVI. We aimed to elucidate the transitional state of bla_KPC variants by selecting CAZ/AVI-sensitive and -resistant CRKP strains from a lung transplantation patient.

Methods

The bla_KPC-variant-carrying CRKP strains were collected from lung transplant recipients exposed to CAZ/AVI in les

SUBMITTER: Lei Z 

PROVIDER: S-EPMC11549737 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature