Changes in central venous-to-arterial PCO₂ difference and central venous oxygen saturation as markers to define fluid responsiveness in critically ill patients: a pot-hoc analysis of a multi-center prospective study.

ABSTRACT:

Background

The main aim of the study whether changes in central venous-to-arterial CO₂ difference (ΔP(v-a)CO₂) and central venous oxygen saturation (ΔScvO₂) induced by volume expansion (VE) are reliable parameters to define fluid responsiveness (FR) in sedated and mechanically ventilated septic patients. We also sought to determine whether the degree of FR was related to baseline ScvO₂ and P(v-a)CO₂ levels.

Methods

This was a post-hoc analysis of a multicenter prospective study. We included 205 mechanically ventilated patients with acute circulatory failure. Cardiac index (CI), P(v-a)CO₂, ScvO₂, and other hemodynamic variables were measured before and after VE. A VE-induced increase in CI > 15% defi

SUBMITTER: Mallat J 

PROVIDER: S-EPMC11549741 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature