Urinary sediment mRNA as a potent biomarker of IgA nephropathy.

ABSTRACT:

Background

The quantification of mRNA expression in urinary sediments is a reliable biomarker for various diseases. However, few studies have investigated the clinical relevance of urinary mRNA levels in IgA nephropathy (IgAN). Thus, we investigated the expression of urinary mRNAs and their clinical significance in IgAN.

Methods

Overall, 200 patients with biopsy-proven IgAN, 48 disease controls, and 76 healthy controls were enrolled. We identified the differential expression of mRNAs in renal tissue between patients with IgAN and normal subjects using the Gene Expression Omnibus dataset and selected candidate mRNAs. mRNA expression in the urinary sediment was measured using quantitative real-time polymerase chain reaction. Associations between urinary mRNA levels and clinico

SUBMITTER: Kim JS 

PROVIDER: S-EPMC11549797 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature