Serum vitamin C levels and risk of osteoporosis: results from a cross-sectional study and Mendelian randomization analysis.

ABSTRACT:

Background

The role of vitamin C as an antioxidant in guarding against osteoporosis in adults is still debated. This research employs both a cross-sectional study and a two-sample bidirectional Mendelian randomization (MR) analysis to explore how serum vitamin C levels correlate with the incidence of osteoporosis among adults.

Methods

In this study, we utilized data from the National Health and Nutrition Examination Survey (NHANES) database for the years 2003-2006, and 2017-2018 to conduct both a cross-sectional analysis and MR to investigate the relationship between serum vitamin C levels and the risk of osteoporosis in adults. We adjusted our analyses for essential demographic and lifestyle variables, and applied logistic regression techniques. Genetic determinants of vita

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11549800 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature