Neutrophil extracellular traps in the cross-talk between periodontitis and chronic kidney disease.

ABSTRACT:

Background

The objective was to evaluate the level of neutrophil extracellular traps (NETs) in patients with chronic kidney disease (CKD) and periodontitis, and to explore the relationship between NETs and both diseases.

Methods

63 CKD and 40 non-CKD participants were recruited and underwent periodontal examination, among which 35 early CKD patients underwent periodontal therapy. The concentrations of NETs were determined by dsDNA assay in gingival crevicular fluid (GCF) and plasma, and by flow cytometry or immunofluorescence assay in blood and gingival tissues. The correlations between NETs and clinical parameters were analyzed. The influence of periodontal therapy on periodontitis, CKD and NETs concentrations was also evaluated.

Results

CKD patients had higher conce

SUBMITTER: Hu S 

PROVIDER: S-EPMC11549809 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature