Deciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis.

ABSTRACT: In this study, we delved into the intrinsic cellular components and transcriptomic signatures characterizing breast-invasive micropapillary carcinoma (IMPC). Employing bulk RNA sequencing, we conducted differential gene expression and functional profiles across breast cancer tissues. Single-cell transcriptome sequencing was performed on mixed IMPC samples. Moreover, a multicenter retrospective cohort of IMPC patients validated the critical role of KRT80. Our findings illuminated heightened activity in redox reactions and metabolism-related functions within IMPC compared to other tissue types. The single-cell atlas of IMPC demonstrated substantial heterogeneity predominantly driven by two distinct cell subsets: epithelioid and interstitial cells. Pseudotime analysis unveiled unique cell tra

SUBMITTER: Xie Y 

PROVIDER: S-EPMC11549989 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature