High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus.

ABSTRACT: Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8⁺CD107a^-IFNγ^-MIP1β^-TNF⁺ T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, th

SUBMITTER: Tong MZW 

PROVIDER: S-EPMC11550119 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature