Serotonin acts through multiple cellular targets during an olfactory critical period.

ABSTRACT: Serotonin (5-HT) modulates early development during critical periods when experience drives heightened levels of plasticity in neurons. Here, we investigate the cellular mechanisms by which 5-HT modulates critical period plasticity (CPP) in the olfactory system of Drosophila. We first demonstrate that 5-HT is necessary for experience-dependent structural plasticity in response to chronic CO₂ exposure and can re-open the critical period long after it normally closes. Knocking down 5-HT7 receptors in a subset of GABAergic local interneurons was sufficient to block CPP, as was knocking down GABA receptors expressed by CO₂-sensing olfactory sensory neurons (OSNs). Furthermore, direct modulation of OSNs via 5-HT2B receptors in CO₂-sensing OSNs and autorec

SUBMITTER: Mallick A 

PROVIDER: S-EPMC11550141 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature