Genome-wide association study identifies DRAM1 associated with Tourette syndrome in Taiwan.

ABSTRACT:

Background

Tourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and vocal tics. Several susceptibility loci associated with TS have been identified previously in populations of European descent using genome-wide association studies (GWAS). However, the exact pathogenic mechanism underlying TS is unknown; additionally, the results of previous GWAS for TS were based on Western populations, which may not translate to other populations. Therefore, we conducted a GWAS in Taiwanese patients with TS and chronic tic disorders (CTDs), with an aim to elucidate the genetic basis and potential risk factors for TS in this population.

Methods

GWAS was performed on a Taiwanese TS/CTDs cohort with a sample size of 1007 patients with TS and 25,522 ancestry-matched c

SUBMITTER: Lin WD 

PROVIDER: S-EPMC11550159 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature