Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC.

ABSTRACT:

Background & aims

Transforming growth factor β (TGF-β) plays an oncogenic role in advanced cancer by promoting cell proliferation, metastasis and immunosuppression. PMEPA1 (prostate transmembrane protein androgen induced 1) has been shown to promote TGF-β oncogenic effects in other tumour types. Thus, we aimed to explore the role of PMEPA1 in hepatocellular carcinoma (HCC).

Methods

We analysed 1,097 tumours from patients with HCC, including discovery (n = 228) and validation (n = 361) cohorts with genomic and clinicopathological data. PMEPA1 levels were assessed by qPCR (n = 228), gene expression data (n = 869) and at the single-cell level (n = 54). Genetically engineered mouse models overexpressing MYC+PMEPA1 compared to MYC were generated

SUBMITTER: Pique-Gili M 

PROVIDER: S-EPMC11550205 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature