Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model.

ABSTRACT: The combination of aminophylline and salbutamol is frequently used in clinical practice in the treatment of obstructive lung diseases. While the side effects (including arrhythmias) of the individual bronchodilator drugs were well described previously, the side effects of combined treatment are almost unknown. We aimed to study the arrhythmogenic potential of combined aminophylline and salbutamol treatment in vitro. For this purpose, we used the established atomic force microscopy (AFM) model coupled with cardiac organoids derived from human pluripotent stem cells (hPSC-CMs). We focused on the chronotropic, inotropic, and arrhythmogenic effects of salbutamol alone and aminophylline and salbutamol combined treatment. We used a method based on heart rate/beat rate variability (HRV/BRV) analy

SUBMITTER: Kabanov D 

PROVIDER: S-EPMC11550379 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature