Single-cell transcriptomic and cross-species comparison analyses reveal distinct molecular changes of porcine testes during puberty.

ABSTRACT: The pig is an important model for studying human diseases and is also a significant livestock species, yet its testicular development remains underexplored. Here, we employ single-cell RNA sequencing to characterize the transcriptomic landscapes across multiple developmental stages of Bama pig testes from fetal stage through infancy, puberty to adulthood, and made comparisons with those of humans and mice. We reveal an exceptionally early onset of porcine meiosis shortly after birth, and identify a distinct subtype of porcine spermatogonia resembling transcriptome state 0 spermatogonial stem cells identified in humans, which were previously thought to be primate specific. We also discover the persistent presence of proliferating progenitors for myoid cells in postnatal testes. The regulato

SUBMITTER: Wang X 

PROVIDER: S-EPMC11550399 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature