Ketamine attenuates kidney damage and depression-like behaviors in mice with cisplatin-induced acute kidney injury.

ABSTRACT: Acute kidney injury (AKI) is a serious condition characterized by decreased urine output, often accompanied by psychiatric symptoms like depression. However, there are limited pharmacological treatments available for AKI and its associated depressive symptoms. In this study, we investigated whether cisplatin-induced AKI in mice leads to depression-like behaviors and whether ketamine could alleviate both the kidney injury and these behaviors. Mice with cisplatin-induced AKI exhibited elevated levels of creatinine and urea, kidney damage, increased kidney injury molecule-1 protein, and pathological changes in the liver, colon, and spleen. They also showed depression-like behaviors and reduced expression of synaptic proteins in the prefrontal cortex. Remarkably, a single dose of ketamine sign

SUBMITTER: Huang T 

PROVIDER: S-EPMC11550419 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature