DNA methylation classifier to diagnose pancreatic ductal adenocarcinoma metastases from different anatomical sites.

ABSTRACT:

Background

We have recently constructed a DNA methylation classifier that can discriminate between pancreatic ductal adenocarcinoma (PAAD) liver metastasis and intrahepatic cholangiocarcinoma (iCCA) with high accuracy (PAAD-iCCA-Classifier). PAAD is one of the leading causes of cancer of unknown primary and diagnosis is based on exclusion of other malignancies. Therefore, our focus was to investigate whether the PAAD-iCCA-Classifier can be used to diagnose PAAD metastases from other sites.

Methods

For this scope, the anomaly detection filter of the initial classifier was expanded by 8 additional mimicker carcinomas, amounting to a total of 10 carcinomas in the negative class. We validated the updated version of the classifier on a validation set, which consisted of a biologi

SUBMITTER: Calina TG 

PROVIDER: S-EPMC11550539 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature