RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms.

ABSTRACT: Variants in the RAS family (HRAS, NRAS and KRAS) are among the most common mutations found in cancer. About 19% patients with cancer harbor RAS mutations, which are typically associated with poor clinical outcomes. Over the past four decades, KRAS has long been considered an undruggable target due to the absence of suitable small-molecule binding sites within its mutant isoforms. However, recent advancements in drug design have made RAS-targeting therapies viable, particularly with the approval of direct KRAS^G12C inhibitors, such as sotorasib and adagrasib, for treating non-small cell lung cancer (NSCLC) with KRAS^G12C mutations. Other KRAS-mutant inhibitors targeting KRAS^G12D are currently being developed for use in the clinic, particularly for treating hig

SUBMITTER: Yang X 

PROVIDER: S-EPMC11550559 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature