Pre-eclampsia intronic polyadenylation enriched in VEGFA-VEGFR2 signaling pathway.

ABSTRACT:

Aims

This study aims to reveal transcriptome-wide intronic polyadenylation (IPA) events associated with Pre-eclampsia (PE).

Background

Pre-eclampsia (PE) is a potentially life-threatening complication of pregnancy, affecting both maternal and fetal health. However, our understanding of the underlying molecular mechanisms of PE remains limited.

Objective

In this study, we conducted a transcriptome-wide analysis of gene expression levels and intronic polyadenylation (IPA) events in samples of patients with PE. We also conducted motif analysis and scanned the microRNA targeting IPA network.

Method

We collected 90 PE-related samples from GEO database. IPA events were analyzed using IPAfinder software from hg38 alignment files from STAR. Miranda software was used to

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11550612 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature