Kinesin-5/Cut7 C-terminal tail phosphorylation is essential for microtubule sliding force and bipolar mitotic spindle assembly.

ABSTRACT: Kinesin-5 motors play an essential role during mitotic spindle assembly in many organisms^{1,2,3,4,5,6,7,8,9,10,11}: they crosslink antiparallel spindle microtubules, step toward plus ends, and slide the microtubules apart.^{12,13,14,15,16,17} This activity separates the spindle poles and chromosomes. Kinesin-5s are not only plus-end-directed but can walk or be carried toward MT minus ends,^18,19,20

SUBMITTER: Jones MH 

PROVIDER: S-EPMC11550858 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature