BCR, not TCR, repertoire diversity is associated with favorable COVID-19 prognosis.

ABSTRACT:

Introduction

The SARS-CoV-2 pandemic has had a widespread and severe impact on society, yet there have also been instances of remarkable recovery, even in critically ill patients.

Materials and methods

In this study, we used single-cell RNA sequencing to analyze the immune responses in recovered and deceased COVID-19 patients during moderate and critical stages.

Results

Expanded T cell receptor (TCR) clones were predominantly SARS-CoV-2-specific, but represented only a small fraction of the total repertoire in all patients. In contrast, while deceased patients exhibited monoclonal B cell receptor (BCR) expansions without COVID-19 specificity, survivors demonstrated diverse and specific BCR clones. These findings suggest that neither TCR diversity nor BCR monoclonal ex

SUBMITTER: Paran FJ 

PROVIDER: S-EPMC11550956 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature