Effects of <i>Abelmoschus manihot</i> (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut-kidney axis.

ABSTRACT:

Background

Clinical observations have recently shown that Abelmoschus manihot (L.) in the form of Huangkui capsule (HKC) and in combination with irbesartan (EB) is an effective therapy for diabetic nephropathy (DN) in patients with type 2 diabetes (T2D). The present study aims to explore the mechanisms underlying the therapeutic efficacies of HKC and its combination with EB in DN via the gut-kidney axis.

Methods

HKC, EB, and their combination or vehicle were administered in db/db mice, which is an animal model for the study of T2D and DN. Comparative analyses of the gut microbiota, serum metabolites, and kidney transcriptomics before and after drug administration were performed.

Results

After treatment with HKC, EB, and their combination for 4 weeks, the urinar

SUBMITTER: Yu H 

PROVIDER: S-EPMC11550981 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature