A genome-wide association study identifies genetic determinants of hemoglobin glycation index with implications across sex and ethnicity.

ABSTRACT:

Introduction

We investigated the genetic determinants of variation in the hemoglobin glycation index (HGI), an emerging biomarker for the risk of diabetes complications.

Methods

We conducted a genome-wide association study (GWAS) for HGI in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (N = 7,913) using linear regression and additive genotype encoding on variants with minor allele frequency greater than 3%. We conducted replication analyses of top findings in the Atherosclerosis Risk in Communities (ARIC) study with inverse variance-weighted meta-analysis. We followed up with stratified GWAS analyses by sex and self-reported race.

Results

In ACCORD, we identified single nucleotide polymorphisms (SNPs) associated with HGI, including a peak

SUBMITTER: House JS 

PROVIDER: S-EPMC11551017 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature