Thalamic Volumes and Functional Networks Linked With Self-Regulation Dysfunction in Major Depressive Disorder.

ABSTRACT:

Aims

Self-regulation (SR) dysfunction is a crucial risk factor for major depressive disorder (MDD). However, neural substrates of SR linking MDD remain unclear.

Methods

Sixty-eight healthy controls and 75 MDD patients were recruited to complete regulatory orientation assessments with the Regulatory Focus Questionnaire (RFQ) and Regulatory Mode Questionnaire (RMQ). Nodal intra and inter-network functional connectivity (FC) was defined as FC sum within networks of 46 thalamic subnuclei (TS) or 88 AAL brain regions, and between the two networks separately. Group-level volumetric and functional difference were compared by two sample t-tests. Pearson's correlation analysis and mediation analysis were utilized to investigate the relationship among imaging parameters and the two be

SUBMITTER: Ling Z 

PROVIDER: S-EPMC11551040 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature