NKp46⁺ ILC3s promote early neutrophil defense against <i>Clostridioides difficile</i> infection through GM-CSF secretion.

ABSTRACT: Clostridioides difficile infection (CDI) is a common cause of antibiotic-associated colitis. C. difficile proliferates and produces toxins that damage the colonic epithelium, leading to symptoms ranging from mild diarrhea to severe pseudomembranous colitis. The host's innate response to CDI occurs in two phases: an early phase in which neutrophils reduce the bacterial load and a late phase involving repair mechanisms to restore epithelial integrity. Group 3 innate lymphoid cells (ILC3s) are crucial in protecting the gut from CDI. Previous studies have shown that ILC3-derived IL-22 is essential in the late phase of CDI for epithelial repair and maintaining an intestinal microbiota that competes with C. difficile, preventing its expansion. Our study finds that ILC3s also

SUBMITTER: Fachi JL 

PROVIDER: S-EPMC11551360 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature