Metabolic engineering of <i>Corynebacterium glutamicum</i> for the production of pyrone and pyridine dicarboxylic acids.

ABSTRACT: Environmental concerns from plastic waste are driving interest in alternative monomers from bio-based sources. Pseudoaromatic dicarboxylic acids are promising alternatives with chemical structures similar to widely used petroleum-based aromatic dicarboxylic acids. However, their use in polyester synthesis has been limited due to production challenges. Here, we report the fermentative production of five pseudoaromatic dicarboxylic acids, including 2-pyrone-4,6-dicarboxylic acid (PDC) and pyridine dicarboxylic acids (PDCAs: 2,3-, 2,4-, 2,5-, and 2,6-PDCA), from glucose using five engineered Corynebacterium glutamicum strains. A platform C. glutamicum chassis strain was constructed by modulating the expression of nine genes involved in the synthesis and degradation pathways of p

SUBMITTER: Cho JS 

PROVIDER: S-EPMC11551391 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature