Capturing the mechanosensitivity of cell proliferation in models of epithelium.

ABSTRACT: Despite the primary role of cell proliferation in tissue development and homeostatic maintenance, the interplay between cell density, cell mechanoresponse, and cell growth and division is not yet understood. In this article, we address this issue by reporting on an experimental investigation of cell proliferation on all time- and length-scales of the development of a model tissue, grown on collagen-coated glass or deformable substrates. Through extensive data analysis, we demonstrate the relation between mechanoresponse and probability for cell division, as a function of the local cell density. Motivated by these results, we construct a minimal model of cell division in tissue environment that can recover the data. By parameterizing the growth and the dividing phases of the cell cycle, and

SUBMITTER: Hollring K 

PROVIDER: S-EPMC11551403 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature