Hyponatremia unleashes neutrophil extracellular traps elevating life-threatening pulmonary embolism risk.

ABSTRACT: Neutrophil extracellular traps (NETs), essential for controlling infections, can induce various pathologies when dysregulated. Known triggers for infection-independent NETs release exist, yet a comprehensive understanding of the conditions prompting such responses is lacking. In this study, we identify hyponatremia as an independent inducer of NETs release, a common clinical condition that disrupts sodium/calcium exchange within neutrophils. This disruption leads to an excess of intracellular calcium, subsequent elevation of reactive oxygen species (ROS), and the citrullination of histone H3, culminating in the activation of NETs-release pathways. Notably, under hyponatremic conditions, this mechanism is exacerbated during infectious states, leading to the deposition of NETs in the lungs a

SUBMITTER: Inoue M 

PROVIDER: S-EPMC11551416 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature