The periaxonal space as a conduit for cerebrospinal fluid flow to peripheral organs.

ABSTRACT: Mechanisms controlling the movement of the cerebrospinal fluid (CSF) toward peripheral nerves are poorly characterized. We found that, in addition to the foramina Magendie and Luschka for CSF flow toward the subarachnoid space and glymphatic system, CSF outflow could also occur along periaxonal spaces (termed "PAS pathway") from the spinal cord to peripheral organs, such as the liver and pancreas. When interrogating the latter route, we found that serotonin, acting through 5-HT_2B receptors expressed in ependymocytes that line the central canal, triggered Ca²⁺ signals to induce polymerization of F-actin, a cytoskeletal protein, to reduce the volume of ependymal cells. This paralleled an increased rate of PAS-mediated CSF redistribution toward peripheral organs. In the

SUBMITTER: Li X 

PROVIDER: S-EPMC11551422 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature