SPATEs promote the survival of <i>Shigella</i> to the plasma complement system upon local hemorrhage and bacteremia.

ABSTRACT: Shigella spp. are the causative agents of shigellosis, which remains a leading cause of death in children under the age of 5. Symptoms of shigellosis include bloody diarrhea, associated to colon hemorrhage; in more severe cases, Shigella bacteremia is induced. These clinical features indicate that Shigella are exposed and survive exposure to plasma, locally and systemically, although this has not yet been studied at a molecular level. In this report, we confirmed in a guinea pig model of shigellosis that both S. flexneri 5a and S. sonnei induced local hemorrhages and we demonstrated that Shigella reached CD31+/CD34+ blood vessels located in the mucosa during the late stages of infection, and further disseminated in the bloodstream. These results co

SUBMITTER: Debande L 

PROVIDER: S-EPMC11551430 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature