Effect of fatty acid profiles in varying recipes of ready-to-use therapeutic foods on neurodevelopmental and clinical outcomes of children (6-59 months) with severe wasting: a systematic review.

ABSTRACT:

Context

In 2020, 13.6 million children under 5 years suffered from severe acute malnutrition (SAM)/wasting. Standard ready-to-use therapeutic foods (RUTFs) improve polyunsaturated fatty acid (PUFA) status but contain suboptimal amounts of omega-3 (n-3) PUFAs with unbalanced n-6-to-n-3 PUFA ratios.

Objectives

The aim was to compare the effects of RUTFs with different essential fatty acid contents on PUFA status, neurodevelopmental, and clinical outcomes (mortality, comorbidities, and recovery) of children with severe wasting.

Data sources

Twelve databases, trial repositories, and article references with no publication limitations.

Data extraction

Ten studies from randomized, quasi, and cluster-randomized controlled trials providing RUTFs as home treatment to chi

SUBMITTER: Nienaber A 

PROVIDER: S-EPMC11551450 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature