Efficacy of a Novel Melatonin-Loaded Gelatin Sponge in Palatal Wound Healing.

ABSTRACT:

Objectives

The aim of this research was to assess both clinically and histologically the effect of a topically applied melatonin-loaded gelatin sponge on palatal wound healing after graft harvesting.

Methods

Twenty-six patients for whom free palatal graft procurement was indicated were divided equally into 2 groups. In the test group, the donor site was covered by a melatonin-loaded gelatin sponge, and in the control group the site was covered by a placebo-loaded gelatin sponge. Wound healing was evaluated on the day of surgery and at 7 and 14 days postsurgery using photo-digital planimetry. Histologic specimens were taken to verify healing type and rate. Pain was assessed via Visual Analogue Scale (VAS) for 7 days from the day of the surgery.

Results

At the 7-day int

SUBMITTER: Hussein SN 

PROVIDER: S-EPMC11551574 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature