Association Between Periodontitis and Preeclampsia: A Bidirectional Mendelian Randomisation Analysis.

ABSTRACT:

Objectives

Studies have increasingly focussed on the relationship between periodontitis (PD) and preeclampsia (PE). However, conclusions have not been consistent, and it is unclear whether any causal relationship exists between them and whether causality is bidirectional. This study employed Mendelian randomisation (MR) analysis to investigate the potential bidirectional causal relationship between PD and PE.

Methods

Genetic variants strongly linked to PD (17,353 cases and 28,210 controls), chronic periodontitis (CP; 1817 cases and 2215 controls), aggressive periodontitis (AgP; 851 cases and 6580 controls), and PE (7212 cases and 194,266 controls) in the genome-wide association study (GWAS) of European ancestry were used as instrumental variables (IVs). Inverse variance weig

SUBMITTER: Cao J 

PROVIDER: S-EPMC11551586 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature