Protein-RNA interactions mediated by silvestrol-insight into a unique molecular clamp.

ABSTRACT: Molecular staples or interfacial inhibitors are small molecules that exert their activity through co-association with macromolecules leading to various effects on target functions. Some molecules inhibit target activity, while others generate gain-of-function complexes. We and others have previously identified two structurally distinct classes of molecular staples, pateamine A and rocaglates. These molecules inhibit eukaryotic initiation factor (eIF) 4A, a critical RNA helicase required for translation initiation, by simultaneously interacting with both RNA and protein components. Structural insights from members of these two families indicate that they wedge themselves between RNA bases during engagement. To extend our understanding of rocaglates, we investigated the RNA-binding propertie

SUBMITTER: Naineni SK 

PROVIDER: S-EPMC11551732 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature