Re-appraising the evidence for the source, regulation and function of p53-family isoforms.

ABSTRACT: The p53 family of proteins evolved from a common ancestor into three separate genes encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each member that lack specific regions or domains are suggested to result from alternative transcription start sites, alternative splicing or alternative translation initiation, and have the potential to exponentially increase the functional repertoire of each gene. However, evidence supporting the presence of individual protein variants at functional levels is often limited and is inferred by mRNA detection using highly sensitive amplification techniques. We provide a critical appraisal of the current evidence for the origins, expression, functions and regulation of p53-family isoforms. We conclude that despite th

SUBMITTER: Lopez I 

PROVIDER: S-EPMC11551734 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature