Core enhancers of the 3'RR optimize IgH nuclear position and loop conformation for successful oriented class switch recombination.

ABSTRACT: In B lymphocytes, class switch recombination (CSR) is an essential process that adapts immunoglobulin (Ig) subtypes to antigen response. Taking place within the Ig heavy chain (IgH) locus, CSR needs controlled transcription of targeted regions governed by the IgH 3' regulatory region (3'RR). This super-enhancer is composed of four core enhancers surrounded by inverted repeated sequences, forming a quasi-palindrome. In addition to transcription, nuclear organization appears to be an important level in CSR regulation. While it is now established that chromatin loop extrusion takes place within IgH locus to facilitate CSR by bringing the donor and acceptor switch regions closer together, the underlying mechanism that triggers CSR loop formation remains partially understood. Here, by combining

SUBMITTER: Bruzeau C 

PROVIDER: S-EPMC11551739 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature