The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer.

ABSTRACT: Angiogenesis is considered essential for tumor progression; however, whether histological counting of blood vessel numbers, expressed as microvessel density (MVD), can be a prognostic factor in breast cancer remains controversial. It has been suggested that the specific morphology of blood vessels such as glomeruloid microvascular proliferation (GMP) is associated with clinical parameters. Here, we aimed to clarify the significance of MVD with revised immunohistochemistry and to identify new blood vessel shapes that predict prognosis in breast cancer. Four hundred and eleven primary breast cancer specimens were collected, and the sections were immunohistochemically stained with CD31 (single staining) and CD31 and Collagen IV (double staining). The prognosis of patients was examined based o

SUBMITTER: Swe HW 

PROVIDER: S-EPMC11551825 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature