Bioprinting PDLSC-Laden Collagen Scaffolds for Periodontal Ligament Regeneration.

ABSTRACT: Periodontitis and severe trauma are major causes of damage to the periodontal ligament (PDL). Repairing the native conditions of the PDL is essential for the stability of the tissue and its interfaces. Bioprinting periodontal ligament stem cells (PDLSCs) is an interesting approach to guide the regeneration of PDL and interfacial integration. Herein, a collagen-based bioink mimicking the native extracellular matrix conditions and carrying PDLSCs was tested to guide the periodontal ligament organization. The bioink was tested at two different concentrations (10 and 15 mg/mL) and characterized by swelling and degradation, microstructural organization, and rheological properties. The biological properties were assessed after loading PDLSCs into bioinks for bioprinting. The characterization was

SUBMITTER: de Souza Araujo IJ 

PROVIDER: S-EPMC11551894 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature