Photocatalytic Degradation of Bacterial Lipopolysaccharides by Peptide-Coated TiO₂ Nanoparticles.

ABSTRACT: In this study, we report the degradation of smooth and rough lipopolysaccharides (LPS) from Gram-negative bacteria and of lipoteichoic acid (LTA) from Gram-positive bacteria by peptide-coated TiO₂ nanoparticles (TiO₂ NPs). While bare TiO₂ NPs displayed minor binding to both LPS and LTA, coating TiO₂ NPs with the antimicrobial peptide LL-37 dramatically increased the level of binding to both LPS and LTA, decorating these uniformly. Importantly, peptide coating did not suppress reactive oxygen species generation of TiO₂ NPs; hence, UV illumination triggered pronounced degradation of LPS and LTA by peptide-coated TiO₂ NPs. Structural consequences of oxidative degradation were examined by neutron reflectometry for smooth LPS, sh

SUBMITTER: Caselli L 

PROVIDER: S-EPMC11551910 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature