Biodegradable ICG-Conjugated Germanium Nanoparticles for <i>In Vivo</i> Near-Infrared Dual-Modality Imaging and Photothermal Therapy.

ABSTRACT: Theranostics, by integrating diagnosis and therapy on a single platform, enables real-time monitoring of tumors during treatment. To improve the accuracy of tumor diagnosis, the fluorescence and photoacoustic imaging modalities can complement each other to achieve high resolution and a deep penetration depth. Despite the superior performance, the biodegradability of theranostic agents plays a critical role in enhancing nanoparticle excretion and reducing chronic toxicity, which is essential for clinical applications. Herein, we synthesize biocompatible and biodegradable indocyanine green (ICG)-conjugated germanium nanoparticles (GeNPs) and investigate their biodistributions in nude mice and 4T1 tumor models after intravenous injections using near-infrared (NIR) dual-modality fluorescence a

SUBMITTER: Chen G 

PROVIDER: S-EPMC11551961 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature