Anti-hypertensives associated with survival in cancer patients receiving immunotherapy: new evidence from a real-world cohort study and meta-analysis.

ABSTRACT:

Background

The efficacy of immune checkpoint inhibitors (ICIs) in cancer patients taking anti-hypertensive drugs is still not well established.

Objective

To elucidate the effect of anti-hypertensive drugs on the clinical outcome of cancer patients receiving immunotherapy.

Design

A retrospective cohort study and meta-analysis.

Method

We conducted a real-world retrospective study of cancer patients treated with immunotherapy at two tertiary centers between January 2019 and June 2023, with primary outcomes being overall survival (OS) and progression-free survival (PFS). In addition, we performed a meta-analysis to synthesize currently relevant clinical studies.

Results

A retrospective clinical study of 336 patients from 2 centers suggested that the use of a

SUBMITTER: Ma P 

PROVIDER: S-EPMC11552054 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature