Minute-scale periodicity of neuronal firing in the human entorhinal cortex.

ABSTRACT: Grid cells in the entorhinal cortex demonstrate spatially periodic firing, thought to provide a spatial map on behaviorally relevant length scales. Whether such periodicity exists for behaviorally relevant time scales in the human brain remains unclear. We investigate neuronal firing during a temporally continuous experience by presenting 14 neurosurgical patients with a video while recording neuronal activity from multiple brain regions. We report on neurons that modulate their activity in a periodic manner across different time scales-from seconds to many minutes, most prevalently in the entorhinal cortex. These neurons remap their dominant periodicity to shorter time scales during a subsequent recognition memory task. When the video is presented at two different speeds, a significant pe

SUBMITTER: M Aghajan Z 

PROVIDER: S-EPMC11552097 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature