More powerful dysregulation of Helicobacter pylori East Asian-type CagA on intracellular signalings.

ABSTRACT:

Background

Chronic infection by Helicobacter pylori strains expressing cytotoxin-associated gene A (CagA) are the strongest risk factor for gastric cancer. CagA can be classified into East Asian-type and Western-type (CagA^E and CagA^W), with CagA^E being more closely associated with gastric cancer. This study aimed to investigate the impact of CagA^E on intracellular signaling pathways to explain its high oncogenicity.

Results

Mutant H. pylori strains expressing either CagA^E or CagA^W were generated by transforming CagA^E/W-expression plasmid into CagA-deleted G27 strain (G27^ΔCagA). In human gastric epithelial cells (GES-1) infection, CagA^E induced more severe cytopathic changes, in

SUBMITTER: Ji X 

PROVIDER: S-EPMC11552142 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature