Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease.

ABSTRACT:

Background

Circular RNAs (circRNAs) are highly stable regulators, often accumulated in mammalian brains and thought to serve as "memory molecules" that govern the long process of aging. Mounting evidence demonstrated circRNA dysregulation in the brains of Alzheimer's disease (AD) patients. However, whether and how circRNA dysregulation underlies AD progression remains unexplored.

Methods

We combined Poly(A)-tailing/RNase R digestion experimental approach with CARP, our published computational framework using pseudo-reference alignment for more sensitive and accurate circRNA detection to identify genome-wide circRNA dysregulation and their downstream pathways in the 5xFAD mouse cerebral cortex between 5 and 7 months of age, a critical window marks the transition from reversib

SUBMITTER: Wang F 

PROVIDER: S-EPMC11552301 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature