Uncovering bacterial-mammalian cell interactions via single-cell tracking.

ABSTRACT:

Background

The interactions between bacterial pathogens and host cells are characterized by a multitude of complexities, leading to a wide range of heterogeneous outcomes. Despite extensive research, we still have a limited understanding of how bacterial motility in complex environments impacts their ability to tolerate antibiotics and adhere to mammalian cell surfaces. The challenge lies in unraveling the complexity of these interactions and developing quantitative microscopy approaches to predict the behavior of bacterial populations.

Results

To address this challenge, we directed our efforts towards Pseudomonas aeruginosa, a pathogenic bacterium known for producing thick films in the lungs of cystic fibrosis patients, and Escherichia coli, used as a proof of concept to de

SUBMITTER: Dewangan NK 

PROVIDER: S-EPMC11552363 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature