Prognostic value of FDX1, the cuprotosis key gene, and its prediction models across imaging modalities and histology.

ABSTRACT:

Background

Cuprotosis has been identified as a novel way of cell death. The key regulator ferredoxin 1 (FDX1) was explored via pan-cancer analysis, and its prediction models were proposed across seven malignancies and two imaging modalities.

Methods

The prognostic value of FDX1 was explored via 1654 cases of 33 types of cancer in the Cancer Genome Atlas database. The MRI cohort of hepatocellular carcinoma in the First Affiliated Hospital of Fujian Medical University, and CT and MRI images from the Cancer Imaging Archive, REMBRANDT and Duke databases were exploited to formulate radiomic models to predict FDX1 expression. After segmentation of volumes of interest and feature extraction, the recursive feature elimination algorithm was used to screen features, logistic regressio

SUBMITTER: Yue Q 

PROVIDER: S-EPMC11552402 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature