TNFSF15 variant predicts disease progression in Chinese patients with Crohn's disease.

ABSTRACT:

Background

The genetic variant of tumor necrosis factor superfamily member 15 (TNFSF15) is associated with Crohn's disease (CD) and the development of intestinal fibrosis and stricturing. We aimed to investigate its predictive role in disease progression and the impact of ileal fibrosis-associated protein expression in Chinese patients with CD.

Methods

We genotyped the single nucleotide polymorphism rs6478109 within the TNFSF15 gene in 428 CD patients and 450 health controls to assess its association with CD. Genotype-phenotype correlation analyses were performed. Mucosal samples from non-diseased terminal ileum were analyzed for TL1A and fibrosis-associated protein expression using western blot and immunohistochemistry.

Results

The G allele frequency of

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11552634 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature