Impact of perioperative chemotherapy on survival in patients with cholangiocarcinoma undergoing curative resection.

ABSTRACT:

Background

Most patients with localized cholangiocarcinoma (CCA) endure cancer relapse after curative resection underscoring the importance of systemic therapy. The current study attempts to determine the impact of perioperative chemotherapy (PC) on survival in patients with CCA undergoing resection.

Methods

Patients diagnosed with CCA undergoing curative-intent resection between January 1, 2000, and December 31, 2019, in a tertiary care center were included. Cox proportional hazard modeling was used to determine the impact of PC on disease-free survival (DFS) and overall survival (OS). In addition, a nomogram was constructed to estimate 3-year DFS.

Results

Among the 182 patients included in the analysis, 102 underwent surgery alone, and 80 received surgery plus PC. F

SUBMITTER: Hassan H 

PROVIDER: S-EPMC11552685 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature