Integrated Epigenetic and Transcriptomic Analysis Identifies <i>Interleukin 17</i> DNA Methylation Signature of Malignant Peripheral Nerve Sheath Tumor Progression and Metastasis.

ABSTRACT:

Purpose

Sarcomas are a complex group of highly aggressive and metastatic tumors with over 100 distinct subtypes. Because of their diversity and rarity, it is challenging to generate multisarcoma signatures that are predictive of patient outcomes.

Materials and methods

Here, we identify a DNA methylation signature for progression and metastasis of numerous sarcoma subtypes using multiple epigenetic and genomic patient data sets. Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are highly metastatic sarcomas with frequent loss of the histone methyltransferase, PRC2. Loss of PRC2 is associated with MPNST metastasis and plays a critical noncanonical role in DNA methylation.

Results

We found that over 900 5'-C-phosphate-G-3' (CpGs) were hypermethylated in MPNSTs wi

SUBMITTER: Brockman QR 

PROVIDER: S-EPMC11552688 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature